FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
ARF6
反应性
Human,Mouse,Rat
应用
WB,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
20kD
推荐稀释比
WB 1:500-1:2000;ELISA 1:10000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from ARF6 . at AA range: 30-110
特异性
ARF6 Polyclonal Antibody detects endogenous levels of ARF6 protein.
基因名称
ARF6
蛋白名称
ADP-ribosylation factor 6
别名
ARF6;ADP-ribosylation factor 6
Organism-1
Human
基因ID-1
382
SwissProt-1
P62330
Organism-2
Mouse
基因ID-2
11845
SwissProt-2
P62331
Organism-3
Rat
基因ID-3
79121
SwissProt-3
P62332
背景
ADP ribosylation factor 6(ARF6) Homo sapiens This gene encodes a member of the human ARF gene family, which is part of the RAS superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7. [provided by RefSeq, Jul 2008],
细胞定位
Cytoplasm, cytosol . Cell membrane ; Lipid-anchor . Endosome membrane ; Lipid-anchor . Recycling endosome membrane ; Lipid-anchor . Cell projection, filopodium membrane ; Lipid-anchor . Cell projection, ruffle . Cleavage furrow . Midbody, Midbody ring . Early endosome membrane ; Lipid-anchor . Golgi apparatus, trans-Golgi network membrane ; Lipid-anchor . Distributed uniformly on the plasma membrane, as well as throughout the cytoplasm during metaphase. Subsequently concentrated at patches in the equatorial region at the onset of cytokinesis, and becomes distributed in the equatorial region concurrent with cleavage furrow ingression. In late stages of cytokinesis, concentrates at the midbody ring/Flemming body (PubMed:23603394). Recruitment to the midbody ring requires both activation by PSD/EFA6A and interaction with KIF23/MKLP1 (PubMed:23603394). After abscission of the intercellular bridge, incorporated into one of the daughter cells as a midbody remnant and localizes to punctate structures beneath the plasma membrane (PubMed:23603394). Recruited to the cell membrane in association with CYTH2 and ARL4C (PubMed:17398095). Colocalizes with DAB2IP at the plasma membrane and endocytic vesicles (PubMed:19948740). Myristoylation is required for proper localization to membranes: myristoylation on Lys-3 allows ARF6 to remain on membranes during the GTPase cycle (PubMed:7589240, PubMed:32103017). .
