FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
AQP4
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
35kD
推荐稀释比
WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:5000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human AQP4. AA range:204-253
特异性
AQP4 Polyclonal Antibody detects endogenous levels of AQP4 protein.
基因名称
AQP4
蛋白名称
Aquaporin-4
别名
AQP4;Aquaporin-4;AQP-4;Mercurial-insensitive water channel;MIWC;WCH4
Organism-1
Human
基因ID-1
361
SwissProt-1
P55087
Organism-2
Mouse
基因ID-2
11829
SwissProt-2
P55088
Organism-3
Rat
基因ID-3
25293
SwissProt-3
P47863
背景
This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2015],
细胞定位
Cell membrane ; Multi-pass membrane protein . Basolateral cell membrane ; Multi-pass membrane protein . Endosome membrane . Cell membrane, sarcolemma ; Multi-pass membrane protein . Cell projection . Activation of the vasopressin receptor AVPR1A triggers AQP4 phosphorylation at Ser-180 and promotes its internalization from the cell membrane. Detected on brain astrocyte processes and astrocyte endfeet close to capillaries. .
