FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
AKAP 250
反应性
Human,Rat,Mouse,
应用
IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Calculated)
191kD
推荐稀释比
IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:20000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human AKAP12. AA range:301-350
特异性
AKAP 250 Polyclonal Antibody detects endogenous levels of AKAP 250 protein.
基因名称
AKAP12
蛋白名称
A-kinase anchor protein 12
别名
AKAP12;AKAP250;A-kinase anchor protein 12;AKAP-12;A-kinase anchor protein 250 kDa;AKAP 250;Gravin;Myasthenia gravis autoantigen
Organism-1
Human
基因ID-1
9590
SwissProt-1
Q02952
Organism-2
Mouse
SwissProt-2
Q9WTQ5
背景
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
细胞定位
Cytoplasm, cell cortex . Cytoplasm, cytoskeleton . Membrane ; Lipid-anchor . May be part of the cortical cytoskeleton.
