FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
3pK
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
42kD
推荐稀释比
WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:20000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human MAPK3. AA range:301-350
特异性
3pK Polyclonal Antibody detects endogenous levels of 3pK protein.
基因名称
MAPKAPK3
蛋白名称
MAP kinase-activated protein kinase 3
别名
MAPKAPK3;MAP kinase-activated protein kinase 3;MAPK-activated protein kinase 3;MAPKAP kinase 3;MAPKAP-K3;MAPKAPK-3;MK-3;Chromosome 3p kinase;3pK
Organism-1
Human
基因ID-1
7867
SwissProt-1
Q16644
Organism-2
Mouse
基因ID-2
102626
SwissProt-2
Q3UMW7
Organism-3
Rat
基因ID-3
315994
SwissProt-3
Q66H84
背景
This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and
细胞定位
Nucleus . Cytoplasm . Predominantly located in the nucleus, when activated it translocates to the cytoplasm.
