FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
14-3-3σ
反应性
Human,Mouse
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
30kD
推荐稀释比
IHC: 100-300;WB 1:500-1:2000;ELISA 1:20000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human SFN. AA range:41-90
特异性
14-3-3 σ Polyclonal Antibody detects endogenous levels of 14-3-3 σ protein.
基因名称
SFN
蛋白名称
14-3-3 protein sigma
别名
SFN;HME1;14-3-3 protein sigma;Epithelial cell marker protein 1;Stratifin
Organism-1
Human
基因ID-1
2810
SwissProt-1
P31947
Organism-2
Mouse
基因ID-2
55948
SwissProt-2
O70456
背景
function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway.,function:p53-regulated inhibitor of G2/M progression.,similarity:Belongs to the 14-3-3 family.,subcellular location:May be secreted by a non-classical secretory pathway.,subunit:Homodimer. Interacts with KRT17 (By similarity). Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN.,tissue specificity:Present mainly in tissues enriched in stratified squamous keratinising epithelium.,
细胞定位
Cytoplasm. Nucleus . Secreted. May be secreted by a non-classical secretory pathway.
