FGF-2 Polyclonal Antibody
¥680.00
Phospho Smad3(S425) mouse Monoclonal Antibody(1D9)
活动价：
¥880.00
市场价：¥1280.00
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产品规格：
- 50μL
货号：
FAB2612595
- 产品信息
商品描述
靶点-Target
Smad3
反应性
Human,Mouse,Rat
应用
IHC,IF
宿主物种-Host Species
Mouse
修饰-Modification
Phospho
MW(Observed)
52kD
推荐稀释比
IHC 1:50-300;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Monoclonal
克隆号
1D9
免疫原
Synthetic Peptide of Phospho-Smad3(S425)
特异性
The antibody detects endogenous Phospho-Smad3(S425) protein
基因名称
SMAD3 MADH3
蛋白名称
Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3)
别名
Mothers against decapentaplegic homolog 3;MAD homolog 3;Mad3;Mothers against DPP homolog 3;hMAD-3;JV15-2;SMAD family member 3;SMAD 3;Smad3;hSMAD3;
Organism-1
Human
基因ID-1
4088
SwissProt-1
P84022
Organism-2
Mouse
SwissProt-2
Q8BUN5
Organism-3
Rat
SwissProt-3
P84025
背景
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis. [provided by RefSeq, Apr 2009],
细胞定位
Cytoplasm . Nucleus . Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 (PubMed:15799969, PubMed:21145499). Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 (PubMed:16751101, PubMed:19289081). Co-localizes with LEMD3 at the nucleus inner membrane (PubMed:15601644). MAPK-mediated phosphorylation appears to have no effect on nuclear import (PubMed:19218245). PDPK1 prevents its nuclear translocation in response to TGF-beta (PubMed:17327236). Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm of the inner cell mass at the blastocyst stage (By similarity). .
