FGF-2 Polyclonal Antibody
¥680.00
Phospho MLKL (S358) mouse Monoclonal Antibody(6F8)
活动价：
¥880.00
市场价：¥1280.00
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产品规格：
- 50μL
货号：
FAB2612594
- 产品信息
商品描述
靶点-Target
MLKL
反应性
Human
应用
IF,IHC
宿主物种-Host Species
Mouse
修饰-Modification
Phospho
MW(Observed)
54kD
推荐稀释比
IF 1:50-200;IHC 1:100-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Monoclonal
克隆号
6F8
免疫原
Synthetic Peptide of phospho-MLKL (S358)
特异性
phospho-MLKL (S358) protein detects endogenous levels of MLKL
基因名称
MLKL
蛋白名称
MLKL
别名
MLKL
Organism-1
Human
基因ID-1
197259
SwissProt-1
Q8NB16
Organism-2
Mouse
SwissProt-2
Q9D2Y4
背景
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015],
细胞定位
Cytoplasm . Cell membrane . Nucleus . Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction (PubMed:24316671). Localizes to the nucleus in response to orthomyxoviruses infection (By similarity). .
