FGF-2 Polyclonal Antibody
¥680.00
Phospho ERK 1/2 (Y222/205)Mouse Monoclonal Antibody(4G3)
活动价：
¥880.00
市场价：¥1280.00
一键复制产品信息
产品规格：
- 50μL
货号：
FAB2612592
- 产品信息
商品描述
靶点-Target
ERK 1/2
反应性
Human,Rat,Mouse
应用
IHC,IF
宿主物种-Host Species
Mouse
修饰-Modification
Phospho
MW(Observed)
44,42kD
推荐稀释比
IHC 1:100-200;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Monoclonal
克隆号
4G3
免疫原
Synthetic Peptide of Phospho-ERK 1/2 (Y222/205) at AA range of 140-220
特异性
Phospho-ERK 1/2 (Y222/205)protein detects endogenous levels of MAPK1/MAPK3
基因名称
MAPK1/MAPK3
蛋白名称
MAPK1/MAPK3
别名
MAPK1/MAPK3
Organism-1
Human
基因ID-1
5594;5595
SwissProt-1
P27361;P28482
基因ID-2
26417;26413
背景
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008],
细胞定位
Cytoplasm . Nucleus. Membrane, caveola . Cell junction, focal adhesion . Autophosphorylation at Thr-207 promotes nuclear localization (PubMed:19060905). PEA15-binding redirects the biological outcome of MAPK3 kinase-signaling by sequestering MAPK3 into the cytoplasm (By similarity). .
