FGF-2 Polyclonal Antibody
¥680.00
MKP-1 (Phospho Ser323) Rabbit pAb
活动价：
¥680.00
市场价：¥880.00
一键复制产品信息
产品规格：
- 50μL
- 100μL
货号：
FAB2612572
- 产品信息
商品描述
靶点-Target
MKP-1
反应性
Human,Mouse,Rat
应用
IHC,WB
宿主物种-Host Species
Rabbit
修饰-Modification
Phospho
MW(Observed)
39kD
推荐稀释比
WB 1:500-2000;IHC 1:50-200
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from human MKP-1 (Phospho Ser323)
特异性
This antibody detects endogenous levels of MKP-1 (Phospho Ser323) Rabbit pAb at Human, Mouse,Rat
基因名称
DUSP1 CL100 MKP1 PTPN10 VH1
蛋白名称
Dual specificity protein phosphatase 1 (Dual specificity protein phosphatase hVH1) (Mitogen-activated protein kinase phosphatase 1) (MAP kinase phosphatase 1) (MKP-1) (Protein-tyrosine phosphatase CL100)
别名
Dual specificity protein phosphatase 1;EC 3.1.3.48;Dual specificity protein phosphatase hVH1;Mitogen-activated protein kinase phosphatase 1;MAP kinase phosphatase 1;MKP-1;Protein-tyrosine phosphatase CL100;
Organism-1
Human
基因ID-1
1843
SwissProt-1
P28562
Organism-2
Mouse
基因ID-2
19252
SwissProt-2
P28563
Organism-3
Rat
基因ID-3
114856
SwissProt-3
Q64623
背景
dual specificity phosphatase 1(DUSP1) Homo sapiens The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferati
细胞定位
Nucleus .
