FGF-2 Polyclonal Antibody
¥680.00
TOPBP1 (Phospho Ser1159) rabbit pAb
活动价：
¥680.00
市场价：¥880.00
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产品规格：
- 50μL
- 100μL
货号：
FAB2612453
- 产品信息
商品描述
靶点-Target
TOPBP1
反应性
Human,Mouse,Rat
应用
WB
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Phospho
MW(Calculated)
167kD
推荐稀释比
WB 1:500-2000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from human TOPBP1 (Phospho-Ser1159)
特异性
This antibody detects endogenous levels of TOPBP1 (Phospho-Ser1159) at Human, Mouse,Rat
基因名称
TOPBP1 KIAA0259
蛋白名称
TOPBP1 (Phospho-Ser1159)
别名
DNA topoisomerase 2-binding protein 1;DNA topoisomerase II-beta-binding protein 1;TopBP1;DNA topoisomerase II-binding protein 1;
Organism-1
Human
基因ID-1
11073
SwissProt-1
Q92547
Organism-2
Mouse
基因ID-2
235559
SwissProt-2
Q6ZQF0
背景
This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands. [provided by RefSeq, Jul 2008],
细胞定位
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Chromosome. Detected on unpaired autosomes in meiotic prophase cells. Detected on X and Y chromosomes during later stages of prophase. Colocalizes with ATR and H2AX at unsynapsed chromosome cores during prophase (By similarity). Has a uniform nuclear distribution during G phase. Colocalizes with BRCA1 at stalled replication forks during S phase. In mitotic cells it colocalizes with BRCA1 at spindle poles and centrosomes during metaphase and anaphase. Detected in discrete foci together with PML and numerous DNA repair enzymes after DNA damage by alkylating agents, UV or gamma irradiation. Localizes to sites of DNA damage in a H2AX- independent manner. .
