FGF-2 Polyclonal Antibody
¥680.00
SREBP-2 (Phospho Ser455) rabbit pAb
活动价：
¥680.00
市场价：¥880.00
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产品规格：
- 50μL
- 100μL
货号：
FAB2612440
- 产品信息
商品描述
靶点-Target
SREBP-2
反应性
Human,Mouse,Rat
应用
WB
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Phospho
MW(Calculated)
126kD
推荐稀释比
WB 1:500-2000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from human SREBP-2 (Phospho-Ser455)
特异性
This antibody detects endogenous levels of SREBP-2 (Phospho-Ser455) at Human, Mouse,Rat
基因名称
SREBF2 BHLHD2 SREBP2
蛋白名称
SREBP-2 (Phospho-Ser455)
别名
Sterol regulatory element-binding protein 2;SREBP-2;Class D basic helix-loop-helix protein 2;bHLHd2;Sterol regulatory element-binding transcription factor 2;[Cleaved into: Processed sterol regulatory element-binding protein 2]
Organism-1
Human
基因ID-1
6721
SwissProt-1
Q12772
Organism-2
Mouse
基因ID-2
20788
SwissProt-2
Q3U1N2
Organism-3
Rat
基因ID-3
300095
SwissProt-3
Q3T1I5
背景
This gene encodes a member of the a ubiquitously expressed transcription factor that controls cholesterol homeostasis by regulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain and binds the sterol regulatory element 1 motif. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],
细胞定位
[Sterol regulatory element-binding protein 2]: Endoplasmic reticulum membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein . Cytoplasmic vesicle, COPII-coated vesicle membrane ; Multi-pass membrane protein . At high sterol concentrations, the SCAP-SREBP is retained in the endoplasmic reticulum (PubMed:32322062). Low sterol concentrations promote recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi, where it is processed (PubMed:32322062). .; [Processed sterol regulatory element-binding protein 2]: Nucleus . Transported into the nucleus with the help of importin-beta. Dimerization of the bHLH domain is a prerequisite for importin beta-dependent nuclear import. .
