FGF-2 Polyclonal Antibody
¥680.00
Stat5 (Phospho Tyr694) rabbit pAb
活动价：
¥680.00
市场价：¥880.00
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产品规格：
- 50μL
- 100μL
货号：
FAB2612260
- 产品信息
商品描述
靶点-Target
Stat5
反应性
Human,Mouse
应用
WB,IHC
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Phospho
MW(Observed)
90kD
推荐稀释比
WB 1:500-2000;IHC 1:50-300
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized phosho peptide around human Stat5 (Tyr694)
特异性
This antibody detects endogenous levels of Human Mouse Stat5 (phospho-Tyr694)
基因名称
STAT5B
蛋白名称
Stat5 (Tyr694)
别名
Signal transducer and activator of transcription 5B
Organism-1
Human
基因ID-1
6777
SwissProt-1
P51692
Organism-2
Mouse
基因ID-2
20851
SwissProt-2
P42232
Organism-3
Rat
基因ID-3
25126
SwissProt-3
P52632
背景
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provi
细胞定位
Cytoplasm . Nucleus . Translocated into the nucleus in response to phosphorylation. .
