FGF-2 Polyclonal Antibody
¥680.00
Rad17 (Phospho Ser635) rabbit pAb
活动价：
¥680.00
市场价：¥880.00
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产品规格：
- 50μL
- 100μL
货号：
FAB2612209
- 产品信息
商品描述
靶点-Target
Rad17
反应性
Human,Rat,Mouse,
应用
WB,ELISA,IHC
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Phospho
MW(Observed)
77kD
推荐稀释比
WB 1:500-2000;IHC 1:50-300;ELISA 1:2000-20000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized phosho peptide around human Rad17 (Ser635)
特异性
This antibody detects endogenous levels of Human Rad17 (phospho-Ser635)
基因名称
RAD17 R24L
蛋白名称
Rad17 (Ser635)
别名
Cell cycle checkpoint protein RAD17;hRad17;RF-C/activator 1 homolog;
Organism-1
Human
基因ID-1
5884
SwissProt-1
O75943
Organism-2
Mouse
基因ID-2
19356
SwissProt-2
Q6NXW6
背景
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, h
细胞定位
Nucleus . Phosphorylated form redistributes to discrete nuclear foci upon DNA damage.
