FGF-2 Polyclonal Antibody
¥680.00
p95/NBS1 (Phospho Ser343) rabbit pAb
活动价：
¥680.00
市场价：¥880.00
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产品规格：
- 50μL
- 100μL
货号：
FAB2612189
- 产品信息
商品描述
靶点-Target
p95/NBS1
反应性
Human,Mouse
应用
WB
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Phospho
MW(Observed)
85kD
推荐稀释比
WB 1:1000-2000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized phosho peptide around human p95 (Ser343)
特异性
This antibody detects endogenous levels of Human Mouse p95 or NBS1 (phospho-Ser343)
基因名称
NBN NBS NBS1 P95
蛋白名称
p95/NBS1 (Ser343)
别名
Nibrin;Cell cycle regulatory protein p95;Nijmegen breakage syndrome protein 1;
Organism-1
Human
基因ID-1
4683
SwissProt-1
O60934
Organism-2
Mouse
基因ID-2
27354
SwissProt-2
Q9R207
Organism-3
Rat
基因ID-3
85482
SwissProt-3
Q9JIL9
背景
Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq, Jul 2008],
细胞定位
Nucleus . Nucleus, PML body . Chromosome, telomere . Chromosome . Localizes to discrete nuclear foci after treatment with genotoxic agents (PubMed:26438602, PubMed:10783165, PubMed:26215093). Acetylation of 'Lys-5' of histone H2AX (H2AXK5ac) promotes NBN/NBS1 assembly at the sites of DNA damage (PubMed:26438602). .
