FGF-2 Polyclonal Antibody
¥680.00
NEDD4L (Phospho Ser448) rabbit pAb
活动价：
¥680.00
市场价：¥880.00
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产品规格：
- 50μL
- 100μL
货号：
FAB2612178
- 产品信息
商品描述
靶点-Target
NEDD4L
反应性
Human,Rat,Mouse,
应用
WB
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Phospho
MW(Observed)
110-120kD
推荐稀释比
WB 1:1000-2000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized phosho peptide around human NEDD4L (Ser448)
特异性
This antibody detects endogenous levels of Human NEDD4L (phospho-Ser448)
基因名称
NEDD4L KIAA0439 NEDL3
蛋白名称
NEDD4L (Ser448)
别名
E3 ubiquitin-protein ligase NEDD4-like;NEDD4.2;Nedd4-2;
Organism-1
Human
基因ID-1
23327
SwissProt-1
Q96PU5
Organism-2
Mouse
SwissProt-2
Q8CFI0
背景
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012],
细胞定位
Cytoplasm . Golgi apparatus . Endosome, multivesicular body . May be recruited to exosomes by NDFIP1.
