FGF-2 Polyclonal Antibody
¥680.00
FGF Receptor 1 (Phospho Tyr653/654) rabbit pAb
活动价：
¥680.00
市场价：¥880.00
一键复制产品信息
产品规格：
- 50μL
- 100μL
货号：
FAB2612101
- 产品信息
商品描述
靶点-Target
FGF Receptor 1
反应性
Human,Rat,Mouse,
应用
WB
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Phospho
MW(Calculated)
120kD
MW(Observed)
full length 120-140kD,FOP-FGFR1 90kD
推荐稀释比
WB 1:1000-2000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized phosho peptide around human FGF Receptor (Tyr653 and 654)
特异性
This antibody detects endogenous levels of Human FGF Receptor (phospho-Tyr653 or 654)
基因名称
FGFR1 BFGFR CEK FGFBR FLG FLT2 HBGFR
蛋白名称
FGF Receptor (Tyr653/654)
别名
Fibroblast growth factor receptor 1;FGFR-1;Basic fibroblast growth factor receptor 1;BFGFR;bFGF-R-1;Fms-like tyrosine kinase 2;FLT-2;N-sam;Proto-oncogene c-Fgr;CD antigen CD331;
Organism-1
Human
基因ID-1
2260
SwissProt-1
P11362
Organism-2
Mouse
基因ID-2
14182
SwissProt-2
P16092
Organism-3
Rat
基因ID-3
79114
SwissProt-3
Q04589
背景
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome,
细胞定位
Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle. After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus.
