FGF-2 Polyclonal Antibody
¥680.00
IGF2R (Phospho Ser2484) Polyclonal Antibody
活动价：
¥680.00
市场价：¥880.00
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产品规格：
- 50μL
- 100μL
货号：
FAB2612015
- 产品信息
商品描述
靶点-Target
IGF2R
反应性
Human,Mouse,Rat
应用
IHC,IF,WB
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Phospho
MW(Observed)
300kD
推荐稀释比
IHC 1:50-200;WB 1:500-2000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from human IGF2R (Phospho-Ser2484)
特异性
This antibody detects endogenous phospho levels of IGF2R (Phospho-Ser2484) at Human:S2484, Mouse:S2476, Rat:S2472
基因名称
IGF2R MPRI
蛋白名称
IGF2R (Phospho-Ser2484)
别名
Cation-independent mannose-6-phosphate receptor;CI Man-6-P receptor;CI-MPR;M6PR;300 kDa mannose 6-phosphate receptor;MPR 300;Insulin-like growth factor 2 receptor;Insulin-like growth factor II receptor;IGF-II receptor;M6P/IGF2 receptor;M6P/IGF2R;CD antigen CD222;
Organism-1
Human
基因ID-1
3482
SwissProt-1
P11717
背景
This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). [provided by RefSeq, Nov 2015],
细胞定位
Golgi apparatus membrane ; Single-pass type I membrane protein . Endosome membrane ; Single-pass type I membrane protein . Mainly localized in the Golgi at steady state and not detectable in lysosome (PubMed:18817523). Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface (PubMed:10900005). .
