GRK2 (Phospho Ser685) Antibody

活动价:

¥680.00

市场价:¥880.00

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产品规格:
  • 50μL
  • 100μL
货号:

FAB2612001

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商品描述
  • 靶点-Target

    GRK 2

  • 反应性

    Human,Mouse,Rat

  • 应用

    WB,ELISA

  • 宿主物种-Host Species

    Rabbit

  • 同种型-Isotype

    IgG

  • 修饰-Modification

    Phospho

  • MW(Observed)

    80kD

  • 推荐稀释比

    WB 1:500-2000;ELISA 1:10000-20000

  • 组成

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • 纯化工艺

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • 储存

    -15°C to -25°C/1 year(Do not lower than -25°C)

  • 浓度

    1 mg/ml

  • 克隆性

    Polyclonal

  • 免疫原

    Synthesized phospho derived from human GRK2 (Phospho-Ser685)

  • 特异性

    This detects endogenous levels of GRK2 (Phospho-Ser685)

  • 基因名称

    ADRBK1 BARK BARK1 GRK2

  • 蛋白名称

    Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (G-protein coupled receptor kinase 2)

  • 别名

    Beta-adrenergic receptor kinase 1;Beta-ARK-1;G-protein coupled receptor kinase 2;

  • Organism-1

    Human

  • 基因ID-1

    156

  • SwissProt-1

    P25098

  • Organism-2

    Mouse

  • SwissProt-2

    Q99MK8

  • Organism-3

    Rat

  • 基因ID-3

    25238

  • SwissProt-3

    P26817

  • 背景

    The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008],

  • 细胞定位

    Cytoplasm . Cell membrane . Cell junction, synapse, postsynapse . Cell junction, synapse, presynapse .