FGF-2 Polyclonal Antibody
¥680.00
Cot (phospho Ser400) Polyclonal Antibody
活动价：
¥680.00
市场价：¥880.00
一键复制产品信息
产品规格：
- 50μL
- 100μL
货号：
FAB2611826
- 产品信息
商品描述
靶点-Target
Cot
反应性
Human,Mouse,Rat
应用
IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Phospho
MW(Calculated)
53kD
推荐稀释比
IHC 1:100-1:300;ELISA 1:5000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human MAP3K8 around the phosphorylation site of Ser400. AA range:366-415
特异性
Phospho-Cot (S400) Polyclonal Antibody detects endogenous levels of Cot protein only when phosphorylated at S400.
基因名称
MAP3K8
蛋白名称
Mitogen-activated protein kinase kinase kinase 8
别名
MAP3K8;COT;ESTF;Mitogen-activated protein kinase kinase kinase 8;Cancer Osaka thyroid oncogene;Proto-oncogene c-Cot;Serine/threonine-protein kinase cot;Tumor progression locus 2;TPL-2
Organism-1
Human
基因ID-1
1326
SwissProt-1
P41279
Organism-2
Mouse
基因ID-2
26410
SwissProt-2
Q07174
Organism-3
Rat
基因ID-3
116596
SwissProt-3
Q63562
背景
This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011],
细胞定位
Cytoplasm .
