FGF-2 Polyclonal Antibody
¥680.00
KCNQ2/3/4/5 (phospho Thr217/246/223/251) Polyclonal Antibody
活动价：
¥680.00
市场价：¥880.00
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产品规格：
- 50μL
- 100μL
货号：
FAB2611784
- 产品信息
商品描述
靶点-Target
KCNQ2/3/4/5
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Phospho
MW(Calculated)
97kD
推荐稀释比
WB 1:500-2000;IHC 1:100-1:300;ELISA 1:20000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human Kv7.3/KCNQ3 around the phosphorylation site of Thr246. AA range:191-240
特异性
Phospho-KCNQ2/3/4/5 (T217/246/223/251) Polyclonal Antibody detects endogenous levels of KCNQ2/3/4/5 protein only when phosphorylated at T217/246/223/251.
基因名称
KCNQ2
蛋白名称
Potassium voltage-gated channel subfamily KQT member 2
别名
KCNQ2;Potassium voltage-gated channel subfamily KQT member 2;KQT-like 2;Neuroblastoma-specific potassium channel subunit alpha KvLQT2;Voltage-gated potassium channel subunit Kv7.2;KCNQ3;Potassium voltage-gated channel subfamily KQT me
Organism-1
Human
基因ID-1
3785;3786;9132;56479
SwissProt-1
O43526;O43525;P56696;Q9NR82
Organism-2
Mouse
基因ID-2
16536;110862;60613;226922
Organism-3
Rat
基因ID-3
170848;29682
SwissProt-3
O88943;O88944;Q9JK96
背景
The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
细胞定位
Cell membrane ; Multi-pass membrane protein .
