FGF-2 Polyclonal Antibody
¥680.00
HAND1 (phospho Ser98) Polyclonal Antibody
活动价：
¥680.00
市场价：¥880.00
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产品规格：
- 50μL
- 100μL
货号：
FAB2611776
- 产品信息
商品描述
靶点-Target
HAND1
反应性
Human,Mouse,Rat
应用
IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Phospho
MW(Calculated)
24kD
推荐稀释比
IHC 1:100-1:300;ELISA 1:10000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human HAND1 around the phosphorylation site of Ser98. AA range:71-120
特异性
Phospho-HAND1 (S98) Polyclonal Antibody detects endogenous levels of HAND1 protein only when phosphorylated at S98.
基因名称
HAND1
蛋白名称
Heart- and neural crest derivatives-expressed protein 1
别名
HAND1;BHLHA27;EHAND;Heart- and neural crest derivatives-expressed protein 1;Class A basic helix-loop-helix protein 27;bHLHa27;Extraembryonic tissues;heart, autonomic nervous system and neural crest derivatives-expressed protein 1;eH
Organism-1
Human
基因ID-1
9421
SwissProt-1
O96004
Organism-2
Mouse
基因ID-2
15110
SwissProt-2
Q64279
Organism-3
Rat
基因ID-3
59112
SwissProt-3
P97832
背景
The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. [provided by RefSeq, Jul 2008],
细胞定位
Nucleus, nucleoplasm . Nucleus, nucleolus . Interaction with MDFIC sequesters it into the nucleolus, preventing the transcription factor activity. Phosphorylation by PLK4 disrupts the interaction with MDFIC and releases it from the nucleolus, leading to transcription factor activity (By similarity). .
