FGF-2 Polyclonal Antibody
¥680.00
Topo IIα (phospho Ser1525) Polyclonal Antibody
活动价：
¥680.00
市场价：¥880.00
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产品规格：
- 50μL
- 100μL
货号：
FAB2611616
- 产品信息
商品描述
靶点-Target
Topo IIα
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Phospho
MW(Observed)
190kD
推荐稀释比
WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:5000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human TOP2A around the phosphorylation site of Ser1525. AA range:1482-1531
特异性
Phospho-Topo IIα (S1525) Polyclonal Antibody detects endogenous levels of Topo IIα protein only when phosphorylated at S1525.
基因名称
TOP2A
蛋白名称
DNA topoisomerase 2-alpha
别名
TOP2A;TOP2;DNA topoisomerase 2-alpha;DNA topoisomerase II;alpha isozyme
Organism-1
Human
基因ID-1
7153
SwissProt-1
P11388
Organism-2
Mouse
基因ID-2
21973
SwissProt-2
Q01320
Organism-3
Rat
基因ID-3
360243
SwissProt-3
P41516
背景
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also pla
细胞定位
Cytoplasm . Nucleus, nucleoplasm . Nucleus . Nucleus, nucleolus .
