FGF-2 Polyclonal Antibody
¥680.00
MDMX (phospho Ser367) Polyclonal Antibody
活动价：
¥680.00
市场价：¥880.00
一键复制产品信息
产品规格：
- 50μL
- 100μL
货号：
FAB2611601
- 产品信息
商品描述
靶点-Target
MDMX
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Phospho
MW(Observed)
80kD
推荐稀释比
WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:5000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human MDM4 around the phosphorylation site of Ser367. AA range:336-385
特异性
Phospho-MDMX (S367) Polyclonal Antibody detects endogenous levels of MDMX protein only when phosphorylated at S367.
基因名称
MDM4
蛋白名称
Protein Mdm4
别名
MDM4;MDMX;Protein Mdm4;Double minute 4 protein;Mdm2-like p53-binding protein;Protein Mdmx;p53-binding protein Mdm4
Organism-1
Human
基因ID-1
4194
SwissProt-1
O15151
Organism-2
Mouse
基因ID-2
17248
SwissProt-2
O35618
Organism-3
Rat
基因ID-3
304798
SwissProt-3
Q5XIN1
背景
This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011],
细胞定位
Nucleus.
