FGF-2 Polyclonal Antibody
¥680.00
LIMK-1/2 (phospho Thr508/505) Polyclonal Antibody
活动价：
¥680.00
市场价：¥880.00
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产品规格：
- 50μL
- 100μL
货号：
FAB2611371
- 产品信息
商品描述
靶点-Target
LIMK-1/2
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Phospho
MW(Observed)
72kD
推荐稀释比
WB 1:500-2000;IHC 1:100-500;IF/ICC1:100-500;ELISA 1:5000-20000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized phospho-peptide around the phosphorylation site of human LIMK-1/2 (phospho Thr508/505)
特异性
Phospho-LIMK-1/2 (T508/505) Polyclonal Antibody detects endogenous levels of LIMK-1/2 protein only when phosphorylated at T508/505.
基因名称
LIMK1/LIMK2
蛋白名称
LIM domain kinase 1/LIM domain kinase 2
别名
LIMK1;LIMK;LIM domain kinase 1;LIMK-1;LIMK2;LIM domain kinase 2;LIMK-2
Organism-1
Human
基因ID-1
3984;3985
SwissProt-1
P53667;P53671
Organism-2
Mouse
基因ID-2
16885;16886
Organism-3
Rat
基因ID-3
29524
SwissProt-3
P53669;P53670
背景
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cog
细胞定位
Cytoplasm . Nucleus . Cytoplasm, cytoskeleton . Cell projection, lamellipodium . Predominantly found in the cytoplasm. Localizes in the lamellipodium in a CDC42BPA, CDC42BPB and FAM89B/LRAP25-dependent manner. .
