FGF-2 Polyclonal Antibody
¥680.00
VDR (phospho Ser208) Polyclonal Antibody
活动价：
¥680.00
市场价：¥880.00
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产品规格：
- 50μL
- 100μL
货号：
FAB2611350
- 产品信息
商品描述
靶点-Target
Vitamin D Receptor
反应性
Human,Rat,Mouse,
应用
WB,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Phospho
MW(Observed)
50kD
推荐稀释比
WB 1:500-1:2000;IF 1:200-1:1000;ELISA 1:10000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human Vitamin D Receptor around the phosphorylation site of Ser208. AA range:181-230
特异性
Phospho-VDR (S208) Polyclonal Antibody detects endogenous levels of VDR protein only when phosphorylated at S208.
基因名称
VDR
蛋白名称
Vitamin D3 receptor
别名
VDR;NR1I1;Vitamin D3 receptor;VDR;1;25-dihydroxyvitamin D3 receptor;Nuclear receptor subfamily 1 group I member 1
Organism-1
Human
基因ID-1
7421
SwissProt-1
P11473
Organism-2
Mouse
SwissProt-2
P48281
背景
This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Feb 2011],
细胞定位
Nucleus . Cytoplasm . Localizes mainly to the nucleus (PubMed:28698609, PubMed:12145331). Localization to the nucleus is enhanced by vitamin D3. .
