FGF-2 Polyclonal Antibody
¥680.00
GRB10 (phospho Tyr67) Polyclonal Antibody
活动价：
¥680.00
市场价：¥880.00
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产品规格：
- 50μL
- 100μL
货号：
FAB2611337
- 产品信息
商品描述
靶点-Target
GRB10
反应性
Human,Rat,Mouse,
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Phospho
MW(Observed)
67kD
推荐稀释比
WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:20000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human GRB10 around the phosphorylation site of Tyr67. AA range:33-82
特异性
Phospho-GRB10 (Y67) Polyclonal Antibody detects endogenous levels of GRB10 protein only when phosphorylated at Y67.
基因名称
GRB10
蛋白名称
Growth factor receptor-bound protein 10
别名
GRB10;GRBIR;KIAA0207;Growth factor receptor-bound protein 10;GRB10 adapter protein;Insulin receptor-binding protein Grb-IR
Organism-1
Human
基因ID-1
2887
SwissProt-1
Q13322
Organism-2
Mouse
SwissProt-2
Q60760
背景
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010],
细胞定位
Cytoplasm . When complexed with NEDD4 and IGF1R, follows IGF1R internalization, remaining associated with early endosomes. Uncouples from IGF1R-containing endosomes before the sorting of the receptor to the lysosomal compartment (By similarity). .
