FGF-2 Polyclonal Antibody
¥680.00
Brk (phospho Tyr447) Polyclonal Antibody
活动价：
¥680.00
市场价：¥880.00
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产品规格：
- 50μL
- 100μL
货号：
FAB2611317
- 产品信息
商品描述
靶点-Target
Brk
反应性
Human,Rat,Mouse,
应用
WB,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Phospho
MW(Observed)
50kD
推荐稀释比
WB 1:500-1:2000;IF 1:200-1:1000;ELISA 1:5000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human Breast Tumor Kinase around the phosphorylation site of Tyr447. AA range:402-451
特异性
Phospho-Brk (Y447) Polyclonal Antibody detects endogenous levels of Brk protein only when phosphorylated at Y447.
基因名称
PTK6
蛋白名称
Protein-tyrosine kinase 6
别名
PTK6;BRK;Protein-tyrosine kinase 6;Breast tumor kinase;Tyrosine-protein kinase BRK
Organism-1
Human
基因ID-1
5753
SwissProt-1
Q13882
Organism-2
Mouse
SwissProt-2
Q64434
背景
protein tyrosine kinase 6(PTK6) Homo sapiens The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012],
细胞定位
Cytoplasm. Nucleus. Cell projection, ruffle. Membrane . Colocalizes with KHDRBS1, KHDRBS2 or KHDRBS3, within the nucleus. Nuclear localization in epithelial cells of normal prostate but cytoplasmic localization in cancer prostate.
