FGF-2 Polyclonal Antibody
¥680.00
Csk (phospho Ser364) Polyclonal Antibody
活动价：
¥680.00
市场价：¥880.00
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产品规格：
- 50μL
- 100μL
货号：
FAB2611077
- 产品信息
商品描述
靶点-Target
Csk
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Phospho
MW(Observed)
55kD
推荐稀释比
WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:10000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human Csk around the phosphorylation site of Ser364. AA range:330-379
特异性
Phospho-Csk (S364) Polyclonal Antibody detects endogenous levels of Csk protein only when phosphorylated at S364.
基因名称
CSK
蛋白名称
Tyrosine-protein kinase CSK
别名
CSK;Tyrosine-protein kinase CSK;C-Src kinase;Protein-tyrosine kinase CYL
Organism-1
Human
基因ID-1
1445
SwissProt-1
P41240
Organism-2
Mouse
基因ID-2
12988
SwissProt-2
P41241
Organism-3
Rat
基因ID-3
315707
SwissProt-3
P32577
背景
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases.,PTM:Autophosphorylation of Tyr-304 occurs only at abnormally high CSK concentrations in vitro.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,subcellular location:Mainly cytoplasmic, also present in lipid rafts.,subunit:Interacts with PTPN8 (By similarity). Interacts with phosphorylated SIT1, PAG1, LIME1 and TGFB1I1.,tissue specificity:Expressed in lung and macrophages.,
细胞定位
Cytoplasm . Cell membrane . Mainly cytoplasmic, also present in lipid rafts. .
