FGF-2 Polyclonal Antibody
¥680.00
Vav1 (phospho Tyr174) Polyclonal Antibody
活动价：
¥680.00
市场价：¥880.00
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产品规格：
- 50μL
- 100μL
货号：
FAB2611055
- 产品信息
商品描述
靶点-Target
VAV1
反应性
Human,Mouse,Rat
应用
WB,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Phospho
MW(Observed)
98kD
推荐稀释比
WB 1:500-1:2000;ELISA 1:10000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human VAV1 around the phosphorylation site of Tyr174. AA range:141-190
特异性
Phospho-Vav1 (Y174) Polyclonal Antibody detects endogenous levels of Vav1 protein only when phosphorylated at Y174.
基因名称
VAV1
蛋白名称
Proto-oncogene vav
别名
VAV1;VAV;Proto-oncogene vav
Organism-1
Human
基因ID-1
7409
SwissProt-1
P15498
Organism-2
Mouse
基因ID-2
22324
SwissProt-2
P27870
Organism-3
Rat
SwissProt-3
P54100
背景
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012],
细胞定位
intracellular,cytosol,plasma membrane,cell-cell junction,
