FGF-2 Polyclonal Antibody
¥680.00
CREB-2 (phospho Ser245) Polyclonal Antibody
活动价：
¥680.00
市场价：¥880.00
一键复制产品信息
产品规格：
- 50μL
- 100μL
货号：
FAB2610857
- 产品信息
商品描述
反应性
Human,Rat,Mouse,
应用
IHC,IF(paraffin section),ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
phospho
推荐稀释比
IHC 1:100 -300;ELISA 1:10000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-20°C/1 year
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human ATF4 around the phosphorylation site of Ser245. AA range:212-261
特异性
Phospho-CREB-2 (S245) Polyclonal Antibody detects endogenous levels of CREB-2 protein only when phosphorylated at S245.
基因名称
ATF4
蛋白名称
Cyclic AMP-dependent transcription factor ATF-4
别名
ATF4;CREB2;TXREB;Cyclic AMP-dependent transcription factor ATF-4;cAMP-dependent transcription factor ATF-4;Activating transcription factor 4;Cyclic AMP-responsive element-binding protein 2;CREB-2;cAMP-responsive element-binding prot
Organism-1
Human
基因ID-1
468
SwissProt-1
P18848
Organism-2
Mouse
SwissProt-2
Q06507
背景
activating transcription factor 4(ATF4) Homo sapiens This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provid
细胞定位
Nucleus . Nucleus speckle . Cytoplasm . Cell membrane . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Colocalizes with GABBR1 in hippocampal neuron dendritic membranes (By similarity). Colocalizes with NEK6 at the centrosome (PubMed:20873783). Recruited to nuclear speckles following interaction with EP300/p300 (PubMed:16219772). .
