FGF-2 Polyclonal Antibody
¥680.00
Chk1 (phospho Ser345) Polyclonal Antibody
活动价：
¥680.00
市场价：¥880.00
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产品规格：
- 50μL
- 100μL
货号：
FAB2610844
- 产品信息
商品描述
靶点-Target
Chk1
反应性
Human,Mouse,Rat
应用
IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Phospho
MW(Calculated)
54kD
推荐稀释比
IHC 1:100-1:300;ELISA 1:10000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human Chk1 around the phosphorylation site of Ser345. AA range:310-359
特异性
Phospho-Chk1 (S345) Polyclonal Antibody detects endogenous levels of Chk1 protein only when phosphorylated at S345.
基因名称
CHEK1
蛋白名称
Serine/threonine-protein kinase Chk1
别名
CHEK1;CHK1;Serine/threonine-protein kinase Chk1;CHK1 checkpoint homolog;Cell cycle checkpoint kinase;Checkpoint kinase-1
Organism-1
Human
基因ID-1
1111
SwissProt-1
O14757
Organism-2
Mouse
基因ID-2
12649
SwissProt-2
O35280
Organism-3
Rat
基因ID-3
140583
SwissProt-3
Q91ZN7
背景
The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011],
细胞定位
Nucleus . Chromosome . Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Nuclear export is mediated at least in part by XPO1/CRM1 (PubMed:12676962). Also localizes to the centrosome specifically during interphase, where it may protect centrosomal CDC2 kinase from inappropriate activation by cytoplasmic CDC25B (PubMed:15311285). Proteolytic cleavage at the C-terminus by SPRTN promotes removal from chromatin (PubMed:31316063). .
