FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
APPL2
反应性
Human,Mouse
应用
WB
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Calculated)
73kD
推荐稀释比
WB 1:500-2000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from human APPL2
特异性
This antibody detects endogenous levels of APPL2 at Human, Mouse
基因名称
APPL2 DIP13B
蛋白名称
DCC-interacting protein 13-beta (Dip13-beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2)
Organism-1
Human
基因ID-1
55198
SwissProt-1
Q8NEU8
Organism-2
Mouse
基因ID-2
216190
SwissProt-2
Q8K3G9
细胞定位
Early endosome membrane ; Peripheral membrane protein . Nucleus . Cell membrane . Endosome membrane . Cytoplasm . Cytoplasmic vesicle, phagosome . Cell projection, ruffle . Cell projection, ruffle membrane . Cell membrane . Cytoplasmic vesicle, phagosome membrane . Early endosomal membrane-bound and nuclear (PubMed:15016378). Translocated into the nucleus upon release from endosomal membranes following internalization of EGF (PubMed:15016378). Associates dynamically with cytoplasmic membrane structures that undergo changes in shape, movement, fusion and fission events (PubMed:18034774). PI(4,5)P2 levels are important for membrane association of APPL2 (PubMed:18034774). Absent of endosome in macrophage. Colocalized with RAB31 at early-stage phagosome (By similarity). Localized on macropinosomes in LPS-activated macrophages. Associated with membrane domains in contact with pathogens and pathogen-derived ligands like LPS. First recruited to the ruffles, and accumulates on macropinosomes (By similarity). .
