FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
AMPKα2
反应性
Human,Mouse,Rat
应用
WB
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
62kD
推荐稀释比
WB 1:1000-2000
组成
PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Polyclonal
免疫原
Recombinant Protein of AMPKα2
特异性
The antibody detects endogenous AMPKα2 protein.
基因名称
PRKAA2
蛋白名称
5'-AMP-activated protein kinase catalytic subunit alpha-2
别名
PRKAA2;AMPK;AMPK2;5'-AMP-activated protein kinase catalytic subunit alpha-2;AMPK subunit alpha-2;Acetyl-CoA carboxylase kinase;ACACA kinase;Hydroxymethylglutaryl-CoA reductase kinase;HMGCR kinase
Organism-1
Human
基因ID-1
5563
SwissProt-1
P54646
Organism-2
Mouse
SwissProt-2
Q8BRK8
Organism-3
Rat
SwissProt-3
Q09137
背景
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008],
细胞定位
Cytoplasm . Nucleus . In response to stress, recruited by p53/TP53 to specific promoters. .
