FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
AMPKβ2
反应性
Human,Mouse,Rat
应用
WB
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
30kD
推荐稀释比
WB 1:1000-2000
组成
PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Polyclonal
免疫原
Recombinant Protein of AMPKβ2
特异性
The antibody detects endogenous AMPKβ2 protein.
基因名称
PRKAB2
蛋白名称
5'-AMP-activated protein kinase subunit beta-2
别名
PRKAB2;5'-AMP-activated protein kinase subunit beta-2;AMPK subunit beta-2
Organism-1
Human
基因ID-1
5565
SwissProt-1
O43741
Organism-2
Mouse
SwissProt-2
Q6PAM0
Organism-3
Rat
SwissProt-3
Q9QZH4
背景
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013],
细胞定位
nucleoplasm,cytosol,nucleotide-activated protein kinase complex,
