FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
CaVα2δ2
反应性
Human,Rat,Mouse
应用
WB,IHC,IF
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
100-120kD
推荐稀释比
WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:40000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthetic Peptide of CaVα2δ2 AA range: 540-620
特异性
The antibody detects endogenous CaVα2δ2 protein
基因名称
CACNA2D2
蛋白名称
Voltage-dependent calcium channel subunit alpha-2/delta-2 (Voltage-gated calcium channel subunit alpha-2/delta-2) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-2; Voltage-dependent calcium channel subunit delta-2]
别名
Voltage-dependent calcium channel subunit alpha-2/delta-2;Voltage-gated calcium channel subunit alpha-2/delta-2;[Cleaved into: Voltage-dependent calcium channel subunit alpha-2-2;Voltage-dependent calcium channel subunit delta-2]
Organism-1
Human
基因ID-1
9254
SwissProt-1
Q9NY47
Organism-2
Mouse
SwissProt-2
Q6PHS9
Organism-3
Rat
SwissProt-3
Q8CFG6
背景
calcium voltage-gated channel auxiliary subunit alpha2delta 2(CACNA2D2) Homo sapiens Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to
细胞定位
Membrane ; Single-pass type I membrane protein . Colocalizes with CACNA1A in lipid raft fractions. .
