FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
DUSP6
反应性
Human,Rat,Mouse
应用
WB
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
42,44kD
推荐稀释比
WB 1:1000-3000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthetic Peptide of DUSP6
特异性
DUSP6 Rabbit Polyclonal detects endogenous levels of DUSP6
基因名称
DUSP6
蛋白名称
Dual specificity protein phosphatase 6 (Dual specificity protein phosphatase PYST1) (Mitogen-activated protein kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3)
别名
DUSP6;MKP3;PYST1;Dual specificity protein phosphatase 6;Dual specificity protein phosphatase PYST1;Mitogen-activated protein kinase phosphatase 3;MAP kinase phosphatase 3;MKP-3
Organism-1
Human
基因ID-1
1848
SwissProt-1
Q16828
Organism-2
Mouse
SwissProt-2
Q9DBB1
Organism-3
Rat
SwissProt-3
Q64346
背景
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in t
细胞定位
Cytoplasm .
