FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
ERK 5
反应性
Human,Mouse,Rat
应用
WB,IHC,IF
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
89-115kD
推荐稀释比
WB 1:1000-2000;IHC 1:200-500;IF 1:50-200
组成
PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Polyclonal
免疫原
Recombinant Protein of ERK 5
特异性
The antibody detects endogenous ERK 5 protein.
基因名称
MAPK7,ERK5
蛋白名称
Mitogen-activated protein kinase 7
别名
MAPK7;BMK1;ERK5;PRKM7;Mitogen-activated protein kinase 7;MAP kinase 7;MAPK 7;Big MAP kinase 1;BMK-1;Extracellular signal-regulated kinase 5;ERK-5
Organism-1
Human
基因ID-1
5598
SwissProt-1
Q13164
Organism-2
Mouse
SwissProt-2
Q9WVS8
Organism-3
Rat
SwissProt-3
P0C865
背景
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008],
细胞定位
Cytoplasm. Nucleus. Nucleus, PML body. Translocates to the nucleus upon activation.
