FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
MeCP2
反应性
Human
应用
WB
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
53kD
推荐稀释比
WB 1:2000
组成
PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Polyclonal
免疫原
Synthetic Peptide of MeCP2 AA range: 313-363
特异性
The antibody detects endogenous MeCP2 proteins.
基因名称
MECP2
蛋白名称
Methyl-CpG-binding protein 2
别名
Methyl-CpG-binding protein 2;MeCp-2 protein;MeCp2;
Organism-1
Human
基因ID-1
4204
SwissProt-1
P51608
Organism-2
Mouse
基因ID-2
17257
SwissProt-2
Q9Z2D6
Organism-3
Rat
基因ID-3
29386
SwissProt-3
Q00566
背景
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Alternative splicing results in multiple transcript variants encoding different isofor
细胞定位
Nucleus . Colocalized with methyl-CpG in the genome. Colocalized with TBL1X to the heterochromatin foci. .
