FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
SPAST
反应性
Human,Mouse,Rat
应用
WB
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Calculated)
68kD
推荐稀释比
WB 1:500-2000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from human SPAST AA range: 163-213
特异性
This antibody detects endogenous levels of SPAST at Human/Mouse/Rat
基因名称
SPAST ADPSP FSP2 KIAA1083 SPG4
蛋白名称
SPAST
Organism-1
Human
基因ID-1
6683
SwissProt-1
Q9UBP0
Organism-2
Mouse
基因ID-2
50850
SwissProt-2
Q9QYY8
Organism-3
Rat
基因ID-3
362700
SwissProt-3
B2RYN7
背景
This gene encodes a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. The encoded ATPase may be involved in the assembly or function of nuclear protein complexes. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their full length sequences have not been determined. Mutations associated with this gene cause the most frequent form of autosomal dominant spastic paraplegia 4. [provided by RefSeq, Jul 2008],
细胞定位
Membrane ; Peripheral membrane protein . Endoplasmic reticulum . Midbody . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton . Cytoplasm, perinuclear region . Nucleus . Cytoplasm, cytoskeleton, spindle . Cytoplasm . Forms an intramembrane hairpin-like structure in the membrane (PubMed:20200447). Localization to the centrosome is independent of microtubules (PubMed:15891913). Localizes to the midbody of dividing cells, and this requires CHMP1B (PubMed:18997780). Enriched in the distal axons and branches of postmitotic neurons (PubMed:15269182). .; [Isoform 1]: Endoplasmic reticulum membrane ; Peripheral membrane protein . Nucleus membrane . Lipid droplet . Cytoplasm, cytoskeleton . Endosome . Forms an intramembrane hairpin-like structure in the membrane (PubMed:20200447). Recruited to nuclear membrane by IST1 during late anaphase (PubMed:26040712). Localizes to endoplasmic reticulum tubular network (PubMed:23969831). .; [Isoform 3]: Cytoplasm . Endosome . Nucleus membrane . Constitutes the main endosomal form (PubMed:19000169). Recruited to nuclear membrane by IST1 during late anaphase (PubMed:26040712). .
