FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
FGD4
反应性
Human,Mouse,Rat
应用
WB
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
85kD
推荐稀释比
WB 1:500-2000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from human FGD4 AA range: 291-341
特异性
This antibody detects endogenous levels of FGD4 at Human/Mouse/Rat
基因名称
FGD4 FRABP ZFYVE6
蛋白名称
FGD4
别名
FYVE, RhoGEF and PH domain-containing protein 4;Actin filament-binding protein frabin;FGD1-related F-actin-binding protein;Zinc finger FYVE domain-containing protein 6;
Organism-1
Human
基因ID-1
121512
SwissProt-1
Q96M96
Organism-2
Mouse
基因ID-2
224014
SwissProt-2
Q91ZT5
Organism-3
Rat
基因ID-3
246174
SwissProt-3
O88387
背景
This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015],
细胞定位
Cytoplasm, cytoskeleton . Cell projection, filopodium . Concentrated in filopodia and poorly detected at lamellipodia. Binds along the sides of actin fibers (By similarity). .
