FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
RUBIC
反应性
Human,Mouse
应用
WB
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
105kD
推荐稀释比
WB 1:500-2000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from human RUBIC AA range: 868-918
特异性
This antibody detects endogenous levels of RUBIC at Human/Mouse
基因名称
KIAA0226
蛋白名称
RUBIC
别名
Run domain Beclin-1 interacting and cystein-rich containing protein;Rubicon;Beclin-1 associated RUN domain containing protein;Baron;
Organism-1
Human
基因ID-1
9711
SwissProt-1
Q92622
Organism-2
Mouse
基因ID-2
100502698
SwissProt-2
Q80U62
背景
The protein encoded by this gene is a negative regulator of autophagy and endocytic trafficking and controls endosome maturation. This protein contains two conserved domains, an N-terminal RUN domain and a C-terminal DUF4206 domain. The RUN domain is involved in Ras-like GTPase signaling, and the DUF4206 domain contains a diacylglycerol (DAG) binding-like motif. Mutation in this gene results in deletion of the DAG binding-like motif and causes a recessive ataxia. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014],
细胞定位
Late endosome . Lysosome . Early endosome . Predominantly located in late endosomes/lysosomes, only partially detected in early endosome and not at all in the Golgi apparatus.
