FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
FBX32
反应性
Human,Mouse,Rat
应用
WB
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
38kD
推荐稀释比
WB 1:500-2000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from human FBX32 AA range: 217-267
特异性
This antibody detects endogenous levels of FBX32 at Human/Mouse/Rat
基因名称
FBXO32
蛋白名称
FBX32
别名
F-box only protein 32;Atrogin-1;Muscle atrophy F-box protein;MAFbx;
Organism-1
Human
基因ID-1
114907
SwissProt-1
Q969P5
Organism-2
Mouse
基因ID-2
67731
SwissProt-2
Q9CPU7
Organism-3
Rat
基因ID-3
171043
SwissProt-3
Q91Z62
背景
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011],
细胞定位
Cytoplasm . Nucleus . Shuttles between cytoplasm and the nucleus.
