FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
YTHD2
反应性
Human,Mouse
应用
WB,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
63kD
推荐稀释比
WB 1:500-2000;ELISA 1:5000-20000
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from part region of human protein
特异性
YTHD2 Polyclonal Antibody detects endogenous levels of protein.
基因名称
YTHDF2 HGRG8
蛋白名称
YTH domain family protein 2 (CLL-associated antigen KW-14) (High-glucose-regulated protein 8) (Renal carcinoma antigen NY-REN-2)
Organism-1
Human
基因ID-1
51441
SwissProt-1
Q9Y5A9
背景
This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene
细胞定位
Cytoplasm, cytosol . Cytoplasm, P-body . Cytoplasm, Stress granule . Nucleus . Localizes to the cytosol and relocates to the nucleus following heat shock stress (PubMed:26458103). Can partition into different structures: into P-bodies in unstressed cells, and into stress granules during stress (PubMed:31292544). .
