FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
IOD2
反应性
Human,Mouse,Rat
应用
WB,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
30kD
推荐稀释比
WB 1:500-2000;ELISA 1:5000-20000
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from part region of human protein
特异性
IOD2 Polyclonal Antibody detects endogenous levels of protein.
基因名称
DIO2 ITDI2 TXDI2
蛋白名称
Type II iodothyronine deiodinase (5DII) (DIOII) (Type 2 DI) (Type-II 5'-deiodinase)
Organism-1
Human
基因ID-1
1734
SwissProt-1
Q92813
Organism-2
Mouse
SwissProt-2
Q9Z1Y9
Organism-3
Rat
SwissProt-3
P70551
背景
deiodinase, iodothyronine type II(DIO2) Homo sapiens The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the conversion of prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4) to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by outer ring 5'-deiodination. This gene is widely expressed, including in thyroid, placenta, pituitary and brain. It is thought to be responsible for the 'local' production of T3, and thus important in influencing thyroid hormone action in these tissues. It has also been reported to be highly expressed in thyroids of patients with Graves disease, and in follicular adenomas. The intrathyroidal T4 to T3 conversion by this enzyme may contribute significantly to the relative increase in thyroidal T3 production in these patients. This protein is a selenoprotein containing the rare selenocysteine (Sec) amino acid at its active site, and may
细胞定位
Membrane ; Single-pass membrane protein .
