FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
CLN3
反应性
Human,Mouse
应用
WB,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
48kD
推荐稀释比
WB 1:500-2000;ELISA 1:5000-20000
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from human protein . at AA range: 221-270
特异性
CLN3 Polyclonal Antibody detects endogenous levels of protein.
基因名称
CLN3 BTS
蛋白名称
Battenin (Batten disease protein) (Protein CLN3)
Organism-1
Human
基因ID-1
1201
SwissProt-1
Q13286
Organism-2
Mouse
SwissProt-2
Q61124
背景
This gene encodes a protein that is involved in lysosomal function. Mutations in this, as well as other neuronal ceroid-lipofuscinosis (CLN) genes, cause neurodegenerative diseases commonly known as Batten disease or collectively known as neuronal ceroid lipofuscinoses (NCLs). Many alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008],
细胞定位
Lysosome membrane ; Multi-pass membrane protein . Late endosome . Lysosome . Golgi apparatus . Golgi apparatus membrane . Golgi apparatus, Golgi stack . Golgi apparatus, trans-Golgi network . Cell membrane . Recycling endosome . Membrane raft . Membrane, caveola . Early endosome membrane . Cell junction, synapse, synaptosome . Late endosome membrane . Cytoplasmic vesicle, autophagosome . CLN3 is not present in late endosomes/lysosomes in fibroblasts and neurons (PubMed:15240864). Trafficks from cell membrane to Golgi via endosomes (PubMed:15240864). Osmotic stress changes the subcellular localization of CLN3 (PubMed:23840424). Trafficks to intracellular compartments via the plasma membranet through AP3M1-dependent mechanisms (PubMed:14644441). Excluded from the synaptic vesicles (By similarity). .
