FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
FURIN
反应性
Human,Rat,Mouse
应用
WB,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
87kD
推荐稀释比
WB 1:500-2000;ELISA 1:5000-20000
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from human protein . at AA range: 340-420
特异性
FURIN Polyclonal Antibody detects endogenous levels of protein.
基因名称
FURIN FUR PACE PCSK3
蛋白名称
Furin (Dibasic-processing enzyme) (Paired basic amino acid residue-cleaving enzyme) (PACE)
Organism-1
Human
基因ID-1
5045
SwissProt-1
P09958
Organism-2
Mouse
SwissProt-2
P23188
Organism-3
Rat
SwissProt-3
P23377
背景
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix m
细胞定位
Golgi apparatus, trans-Golgi network membrane ; Single-pass type I membrane protein . Cell membrane ; Single-pass type I membrane protein . Secreted . Endosome membrane ; Single-pass type I membrane protein . Shuttles between the trans-Golgi network and the cell surface (PubMed:9412467, PubMed:11799113). Propeptide cleavage is a prerequisite for exit of furin molecules out of the endoplasmic reticulum (ER). A second cleavage within the propeptide occurs in the trans Golgi network (TGN), followed by the release of the propeptide and the activation of furin (PubMed:11799113). .
