FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
RGMC
反应性
Human,Rat,Mouse
应用
WB,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
46kD
推荐稀释比
WB 1:500-2000;ELISA 1:5000-20000
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from human protein . at AA range: 270-350
特异性
RGMC Polyclonal Antibody detects endogenous levels of protein.
基因名称
HFE2 HJV RGMC
蛋白名称
Hemojuvelin (Hemochromatosis type 2 protein) (RGM domain family member C)
Organism-1
Human
基因ID-1
148738
SwissProt-1
Q6ZVN8
Organism-2
Mouse
SwissProt-2
Q7TQ32
Organism-3
Rat
SwissProt-3
Q8N7M5
背景
hemochromatosis type 2 (juvenile)(HFE2) Homo sapiens The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Two uORFs in the 5' UTR negatively regulate the expression and activity of the encoded protein. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30. [provided by RefSeq, Oct 2015],
细胞定位
Cell membrane ; Lipid-anchor, GPI-anchor . Also released in the extracellular space. .
