FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
IL18
反应性
Human,Rat,Mouse
应用
WB IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
21kD
推荐稀释比
WB 1:500-2000;IF 1:100-300;ELISA 1:5000-20000;Not yet tested in other applications.
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from part region of human protein
特异性
IL18 Polyclonal Antibody detects endogenous levels of protein.
基因名称
IL18 IGIF IL1F4
蛋白名称
Interleukin-18 (IL-18) (Iboctadekin) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
Organism-1
Human
基因ID-1
3606
SwissProt-1
Q14116
Organism-2
Mouse
SwissProt-2
P70380
Organism-3
Rat
SwissProt-3
P97636
背景
The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011],
细胞定位
Cytoplasm . Secreted . The precursor is cytosolic (PubMed:33883744). In response to inflammasome-activating signals, cleaved and secreted (PubMed:33883744). Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744). In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation (PubMed:33883744). The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10 (PubMed:32272059). .
