FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
KAISO
反应性
Human,Mouse
应用
WB,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
73kD
推荐稀释比
WB 1:500-2000;ELISA 1:5000-20000
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from human protein . at AA range: 100-180
特异性
KAISO Polyclonal Antibody detects endogenous levels of protein.
基因名称
ZBTB33 KAISO ZNF348
蛋白名称
Transcriptional regulator Kaiso (Zinc finger and BTB domain-containing protein 33)
Organism-1
Human
基因ID-1
10009
SwissProt-1
Q86T24
Organism-2
Mouse
SwissProt-2
Q8BN78
背景
This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear impor
细胞定位
Nucleus . Cytoplasm . Also cytoplasmic in cells grown at high densities.
