FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
PLXB1
反应性
Human,Mouse
应用
WB,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
234kD
推荐稀释比
WB 1:500-2000;ELISA 1:5000-20000
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from human protein . at AA range: 90-170
特异性
PLXB1 Polyclonal Antibody detects endogenous levels of protein.
基因名称
PLXNB1 KIAA0407 PLXN5 SEP
蛋白名称
Plexin-B1 (Semaphorin receptor SEP)
Organism-1
Human
基因ID-1
5364
SwissProt-1
O43157
Organism-2
Mouse
SwissProt-2
Q8CJH3
背景
disease:Overexpressed and constitutively tyrosine phosphorylated in colon, liver, pancreas and gastric carcinoma cell lines. Overexpression increases MET activation and promotes invasive growth.,function:Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.,PTM:Phosphorylated on tyrosine residues by ERBB2 and MET upon SEMA4D binding.,PTM:Proteolytic processing favors heterodimerization with PLXNB2 and SEMA4D binding.,similarity:Belongs to the plexin family.,similarity:Contains 1 Sema domain.,similarity:Contains 3 IPT/TIG domains.,subunit:Monomer, and heterodimer with PLXNB2 after proteolytic processing. Binds RAC1 that has been activated by GTP binding. Interaction with SEMA4D promotes binding of cytoplasmic ligands. Binds PLXNA1 (By similarity). Binds ARHGEF11, ARHGEF12, ERBB2, MET, MST1R, RND1, NRP1 and NRP2.,tissue specificity:Highly expressed in fetal kidney, and at slightly lower levels in fetal brain, lung and liver.,
细胞定位
[Isoform 1]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 2]: Secreted .; [Isoform 3]: Secreted .
